Joint consensus statement on the vaccination of adult and paediatric haematopoietic stem cell transplant recipients: Prepared on behalf of the British society of blood and marrow transplantation and cellular therapy (BSBMTCT), the Children's cancer and Leukaemia Group (CCLG), and British Infection Association (BIA)

Pde Miller; S R Patel; R Skinner; F Dignan; A Richter; K Jeffery; A Khan; P T Heath; A Clark; K Orchard; J A Snowden; T I de Silva

doi:10.1016/j.jinf.2022.11.005

Joint consensus statement on the vaccination of adult and paediatric haematopoietic stem cell transplant recipients: Prepared on behalf of the British society of blood and marrow transplantation and cellular therapy (BSBMTCT), the Children's cancer and Leukaemia Group (CCLG), and British Infection Association (BIA)

J Infect. 2023 Jan;86(1):1-8. doi: 10.1016/j.jinf.2022.11.005. Epub 2022 Nov 15.

Authors

Pde Miller¹, S R Patel², R Skinner³, F Dignan⁴, A Richter⁵, K Jeffery⁶, A Khan⁷, P T Heath⁸, A Clark⁹, K Orchard¹⁰, J A Snowden¹¹, T I de Silva¹²

Affiliations

¹ British Society of Blood and Marrow Transplantation and Cellular Therapy, UK.
² Paediatric Department, Croydon Health Services NHS Trust, Croydon, UK.
³ University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
⁴ Department of Clinical Haematology, University of Manchester, Manchester, UK.
⁵ Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
⁶ Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
⁷ St. James' Hospital, Leeds, UK.
⁸ Vaccine Institute, Institute of Infection and Immunity, St. George's, University of London, London, UK.
⁹ NHS Greater Glasgow and Clyde, Glasgow, UK.
¹⁰ Wessex Blood and Marrow Transplant and Cellular Therapy Program, Department of Haematology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
¹¹ Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK; Department of Oncology and Metabolism, Medical School, The University of Sheffield, Sheffield, UK.
¹² Department of Infection, Immunity and Cardiovascular Disease, Medical School, The University of Sheffield, Sheffield, UK. Electronic address: t.desilva@sheffield.ac.uk.

PMID: 36400155
DOI: 10.1016/j.jinf.2022.11.005

Abstract

Haematopoietic stem cell transplant (HSCT) recipients have deficiencies in their adaptive immunity against vaccine preventable diseases. National and International guidance recommends that HSCT recipients are considered 'never vaccinated' and offered a comprehensive course of revaccination. This position statement aims to draw upon the current evidence base and existing guidelines, and align this with national vaccine availability and licensing considerations in order to recommend a pragmatic and standardised re-vaccination schedule for adult and paediatric HSCT recipients in the UK.

Keywords: Haematopoietic stem cell transplant; Immunisation; Vaccination.

Publication types

Review

MeSH terms

Adult
Bone Marrow
Child
Hematopoietic Stem Cell Transplantation*
Humans
Leukemia*
Transplant Recipients
Vaccination
Vaccines

Substances

Vaccines

Grants and funding

MR/W020653/1/MRC_/Medical Research Council/United Kingdom