The associations of particulate matter short-term exposure and serum lipids are modified by vitamin D status: A panel study of young healthy adults

Jia-Min Li; Han-Yu Yang; Si-Han Wu; Shyamali C Dharmage; Bin Jalaludin; Luke D Knibbs; Michael S Bloom; Yuming Guo; Lidia Morawska; Joachim Heinrich; Yim Steve Hung Lam; Li-Zi Lin; Xiao-Wen Zeng; Bo-Yi Yang; Gong-Bo Chen; Ru-Qing Liu; Guang-Hui Dong; Li-Wen Hu

doi:10.1016/j.envpol.2022.120686

The associations of particulate matter short-term exposure and serum lipids are modified by vitamin D status: A panel study of young healthy adults

Environ Pollut. 2023 Jan 15:317:120686. doi: 10.1016/j.envpol.2022.120686. Epub 2022 Nov 15.

Authors

Jia-Min Li¹, Han-Yu Yang¹, Si-Han Wu¹, Shyamali C Dharmage², Bin Jalaludin³, Luke D Knibbs⁴, Michael S Bloom⁵, Yuming Guo⁶, Lidia Morawska⁷, Joachim Heinrich⁸, Yim Steve Hung Lam⁹, Li-Zi Lin¹, Xiao-Wen Zeng¹, Bo-Yi Yang¹, Gong-Bo Chen¹, Ru-Qing Liu¹, Guang-Hui Dong¹, Li-Wen Hu¹⁰

Affiliations

¹ Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510080, China.
² Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population & Global Health, The University of Melbourne, Melbourne, VIC, 3010, Australia.
³ Centre for Research, Evidence Management and Surveillance, South Western Sydney Local Health District, Liverpool, NSW, 2037, Australia; Ingham Institute for Applied Medical Research, Liverpool, NSW, 2170, Australia; School of Public Health and Community Medicine Sydney, University of New South Wales, Sydney, NSW, 2052, Australia.
⁴ School of Public Health, The University of Sydney, NSW, 2006, Australia.
⁵ Department of Global and Community Health, George Mason University, Fairfax, VA, 22030, USA.
⁶ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
⁷ Queensland University of Technology, International Laboratory for Air Quality & Health, Brisbane, QLD, Australia; Queensland University of Technology, Science and Engineering Faculty, Brisbane, QLD, Australia.
⁸ Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Ziemssenstraße 1, 80336, Munich, Germany; Comprehensive Pneumology Center Munich, German Center for Lung Research, Ziemssenstraße 1, 80336, Munich, Germany.
⁹ Asian School of the Environment, Nanyang Technological University, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Earth Observatory of Singapore, Nanyang Technological University, Singapore.
¹⁰ Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510080, China. Electronic address: huliwen@mail.sysu.edu.cn.

PMID: 36400145
DOI: 10.1016/j.envpol.2022.120686

Abstract

Particulate matter (PM) exposure is associated to the adverse change in blood lipids. Vitamin D is beneficial to lipid metabolism, but whether vitamin D levels modifies the impact of air pollutants on lipids is unclear. The purpose of the study was to investigate if vitamin D modifies the associations of PM and serum lipids in young healthy people. From December 2017 to January 2018, a panel study with five once weekly follow-ups was conducted on 88 healthy adults aged 21.09 (1.08) (mean (SD)) years on average in Guangzhou, China. We measured serum lipids, serum 25-hydroxyvitamin D (25(OH)D) concentrations (440 blood samples in total), mass concentrations of particulate matter with diameters ≤2.5 μm (PM_2.5), ≤1.0 μm (PM_1.0), and ≤0.5 μm (PM_0.5), and number concentrations of particulate matter with diameters ≤0.2 μm (PN_0.2) and ≤0.1 μm (PN_0.1) at each follow-up. Linear mixed-effect models were applied to assess the interaction of vitamin D and size-fractionated PM short-term exposure on four lipid metrics. We found the interactions between 25(OH)D and size-fractionated PM exposure on blood lipids in different lags (lag 3 days and 4 days). An interquartile range increase in PM_2.5, PM_1.0, PM_0.5 were significantly associated with increments of 12.30%, 12.99%, and 13.66% in triglycerides (TGs) at lag 4 days at vitamin D levels <15 ng/mL group, respectively. Similar results were found for PN_0.2, PN_0.1 and low-density lipoprotein cholesterol (LDL-C). All the associations between size-fractionated PM and blood lipids were found null statistically significant in vitamin D levels ≥15 ng/mL group.

Keywords: Blood lipids; Interaction; Particulate matter; Vitamin D.

MeSH terms

Adult
Air Pollutants* / analysis
Air Pollution* / analysis
China
Environmental Exposure
Humans
Lipids
Particulate Matter / analysis
Vitamin D
Vitamins

Substances

Particulate Matter
Air Pollutants
Vitamin D
Vitamins
Lipids