Incidental FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci

Virchows Arch. 2023 Jul;483(1):117-124. doi: 10.1007/s00428-022-03452-y. Epub 2022 Nov 18.

Abstract

We report on the incidental finding of a FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci, a rare entity recently described by Jennifer N. Stall and Robert H. Young in a series of sixteen cases in 2019, displaying features differing from conventional adult granulosa cell tumour. Our aim is to specify the morphologic and molecular particularities of this presumably underrecognized finding, with a short presentation of the typical clinical context. Awareness of this rare and challenging neoplasm with indeterminate clinical course is crucial in routine diagnostics.

Keywords: Adult granulosa cell tumour; FOXL2 mutation; Functioning ovarian neoplasms; Reticulin staining; Thecoma-like foci.

MeSH terms

  • Adult
  • Female
  • Forkhead Box Protein L2 / genetics
  • Forkhead Transcription Factors / genetics
  • Granulosa Cell Tumor* / diagnosis
  • Granulosa Cell Tumor* / genetics
  • Granulosa Cell Tumor* / pathology
  • Humans
  • Ovarian Neoplasms* / genetics
  • Ovarian Neoplasms* / pathology
  • Thecoma* / diagnosis
  • Thecoma* / genetics
  • Thecoma* / pathology

Substances

  • Forkhead Box Protein L2
  • Forkhead Transcription Factors
  • FOXL2 protein, human

Supplementary concepts

  • Granulosa cell tumor of the ovary