Ciliogenesis is intrinsically altered in COPD small airways

Emilie Luczka-Majérus; Arnaud Bonnomet; Adeline Germain; Nathalie Lalun; Claire Kileztky; Jeanne-Marie Perotin; Gaëtan Deslée; Gonzague Delepine; Myriam Polette; Valérian Dormoy; Christelle Coraux

doi:10.1183/13993003.00791-2022

Ciliogenesis is intrinsically altered in COPD small airways

Eur Respir J. 2022 Dec 22;60(6):2200791. doi: 10.1183/13993003.00791-2022. Print 2022 Dec.

Authors

Emilie Luczka-Majérus¹, Arnaud Bonnomet^{1

2}, Adeline Germain¹, Nathalie Lalun¹, Claire Kileztky¹, Jeanne-Marie Perotin^{1

3}, Gaëtan Deslée^{1

3}, Gonzague Delepine^{1

4}, Myriam Polette^{1

5}, Valérian Dormoy¹, Christelle Coraux⁶

Affiliations

¹ Inserm UMR-S 1250, University of Reims Champagne-Ardenne (URCA), SFR Cap-Santé, Reims, France.
² PICT Platform, University of Reims Champagne-Ardenne (URCA), Reims, France.
³ Dept of Respiratory Diseases, University Hospital of Reims, Reims, France.
⁴ Dept of Cardio-Thoracic Surgery, University Hospital of Reims, Reims, France.
⁵ Dept of Biopathology, University Hospital of Reims, Reims, France.
⁶ Inserm UMR-S 1250, University of Reims Champagne-Ardenne (URCA), SFR Cap-Santé, Reims, France christelle.coraux@univ-reims.fr.

Abstract

An alteration of primary and motile ciliogenesis is detected in mild/moderate COPD small airways and could be at the origin of the initiation of epithelial remodelling http://bit.ly/3Tz3JDj

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Lung
Pulmonary Disease, Chronic Obstructive*