Neuropharmacological interventions of quercetin and its derivatives in neurological and psychological disorders

Kirti Agrawal; Pratik Chakraborty; Saikat Dewanjee; Saniya Arfin; Sabya Sachi Das; Abhijit Dey; Mahmoud Moustafa; Prabhu Chandra Mishra; Seid Mahdi Jafari; Niraj Kumar Jha; Saurabh Kumar Jha; Dhruv Kumar

doi:10.1016/j.neubiorev.2022.104955

Neuropharmacological interventions of quercetin and its derivatives in neurological and psychological disorders

Neurosci Biobehav Rev. 2023 Jan:144:104955. doi: 10.1016/j.neubiorev.2022.104955. Epub 2022 Nov 14.

Authors

Affiliations

¹ School of Health sciences & Technology, UPES University, Dehradun, Uttarakhand, India, 248007.
² Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, West Bengal, India.
³ School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun 248009, Uttarakhand, India.
⁴ Department of Life Sciences, Presidency University, Kolkata 700073, West Bengal, India.
⁵ Department of Biology, Faculty of Science, King Khalid University, Abha, Saudi Arabia; Department of Botany and Microbiology, Faculty of Science, South Valley University, Qena, Egypt.
⁶ Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, India.
⁷ Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran; Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, E-32004 Ourense, Spain.
⁸ Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, India. Electronic address: nirajkumarjha2011@gmail.com.
⁹ Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, Uttar Pradesh 201310, India; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali 140413, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India. Electronic address: saurabh.jha@sharda.ac.in.
¹⁰ School of Health sciences & Technology, UPES University, Dehradun, Uttarakhand, India, 248007. Electronic address: dhruvbhu@gmail.com.

PMID: 36395983
DOI: 10.1016/j.neubiorev.2022.104955

Abstract

Quercetin is a naturally occurring bioactive flavonoid abundant in many plants and fruits. Quercetin and its derivatives have shown an array of pharmacological activities in preclinical tests against various illnesses and ailments. Owing to its protective role against oxidative stress and neuroinflammation, quercetin is a possible therapeutic choice for the treatment of neurological disorders. Quercetin and its derivatives can modulate a variety of signal transductions, including neuroreceptor, neuroinflammatory receptor, and redox signaling events. The research on quercetin and its derivatives in neurology-related illnesses mainly focused on the targets, such as redox stress, neuroinflammation, and signaling pathways; however, the function of quercetin and its derivatives on specific molecular targets, such as nuclear receptors and proinflammatory mediators are yet to be explored. Findings showed that various molecular targets of quercetin and its derivatives have therapeutic potential against psychological and neurodegenerative disorders.

Keywords: Anxiety; Depression; Neurodegenerative disorders; Psychological disorders (PLDs); Quercetin; Quercetin derivatives.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants
Humans
Mental Disorders* / drug therapy
Neurodegenerative Diseases* / drug therapy
Neuroinflammatory Diseases
Quercetin / pharmacology
Quercetin / therapeutic use

Substances

Quercetin
Antioxidants