Should I stay, or should I go? Gene retention in organellar genomes

Lantana K Grub; Nikita Tsyba; Maulik R Patel

doi:10.1016/j.cels.2022.10.006

Should I stay, or should I go? Gene retention in organellar genomes

Cell Syst. 2022 Nov 16;13(11):861-863. doi: 10.1016/j.cels.2022.10.006.

Authors

Lantana K Grub¹, Nikita Tsyba¹, Maulik R Patel²

Affiliations

¹ Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.
² Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA; Evolutionary Studies, Vanderbilt University, Nashville, TN 37235, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA; Diabetes Research and Training Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: maulik.r.patel@vanderbilt.edu.

PMID: 36395725
DOI: 10.1016/j.cels.2022.10.006

Abstract

Mitochondria and plastids retain their own small but essential genomes. However, the evolutionary pressures that determine whether a gene is retained in organellar DNA or exported to the "host" nuclear genome remain unclear. A new study in Cell Systems addresses this knowledge gap using bioinformatic data and modeling to identify universal "rules" that determine organellar gene retention.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Nucleus* / genetics
Computational Biology
DNA
Genome* / genetics
Mitochondria / genetics

Substances

DNA

Abstract

Publication types

MeSH terms

Substances

Grants and funding