The intracellular pathogen Listeria monocytogenes is one of the leading causes of death from foodborne illness in the United States. Internalin A is the key surface protein that drives Listeria uptake by epithelial cells expressing E-cadherin. G. C. Gyanwali, T. U. B. Herath, A. Gianfelice, and K. Ireton (Infect Immun 90:e00326-22, 2022, https://doi.org/10.1128/iai.00326-22) unravel the close relationship between internalin A and the exocyst, adding another layer of complexity to the bacterial internalization process.
Keywords: InlA-coated particles; bacterial entry; focal exocytosis; siRNA.