Recent advances in surgical strategies and liver transplantation for hepatoblastoma

Cancer Med. 2023 Feb;12(4):3909-3918. doi: 10.1002/cam4.5300. Epub 2022 Nov 16.

Abstract

Hepatoblastoma (HB) is the most common malignant liver tumor in children. Although the development of treatment strategies with advances in chemotherapy has greatly improved the prognosis of HB, surgical resection and liver transplantation still play a vital role in the treatment of HB. In recent years, technological innovations have led to the development of new surgical approaches for HB. In this review, we describe the latest research on the surgical management of HB, including new imaging technologies, minimally invasive approaches, and the application of associating liver partition portal vein ligation for staged hepatectomy. We also discuss the current role of liver transplantation, use of ante-situm or ex-situ liver resection with auto-transplantation, and management of metastatic HB.

Keywords: associating liver partition and portal vein ligation for staged hepatectomy; hepatoblastoma; indocyanine green navigation surgery; liver transplantation; minimally invasive surgery.

Publication types

  • Review

MeSH terms

  • Child
  • Hepatectomy / methods
  • Hepatoblastoma* / pathology
  • Hepatoblastoma* / surgery
  • Humans
  • Liver / pathology
  • Liver Neoplasms* / pathology
  • Liver Transplantation*
  • Treatment Outcome