New insight into the molecular mechanism of miR482/2118 during plant resistance to pathogens

Lijuan Liao; Biao Xie; Peipei Guan; Ning Jiang; Jun Cui

doi:10.3389/fpls.2022.1026762

New insight into the molecular mechanism of miR482/2118 during plant resistance to pathogens

Front Plant Sci. 2022 Oct 28:13:1026762. doi: 10.3389/fpls.2022.1026762. eCollection 2022.

Authors

Lijuan Liao^{1

2}, Biao Xie^{1

3}, Peipei Guan^{1

2}, Ning Jiang⁴, Jun Cui^{1

2}

Affiliations

¹ College of Life Science, Hunan Normal University, Changsha, China.
² Hunan Provincial Key Laboratory for Microbial Molecular Biology, Changsha, China.
³ The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, Changsha, China.
⁴ Hunan Academy of Agricultural Sciences, Changsha, China.

Abstract

MicroRNAs (miRNAs), a group of small noncoding RNAs (approximately 20-24 nucleotides), act as essential regulators affecting endogenous gene expression in plants. MiR482/2118 is a unique miRNA superfamily in plants and represses NUCLEOTIDE BINDING SITE-LEUCINE-RICH REPEAT (NBS-LRR) genes to function in plant resistance to pathogens. In addition, over the past several years, it has been found that miR482/2118 not only targets NBS-LRRs but also acts on other molecular mechanisms to affect plant resistance. miR482/2118-5ps, phased small interfering RNAs (phasiRNAs) and long noncoding RNAs (lncRNAs) play important roles in plant disease resistance. This review summarizes the current knowledge of the interactions and links between miR482/2118 and its new interacting molecules, miR482/2118-5p, phasiRNAs and lncRNAs, in plant disease resistance. Here, we aim to provide a comprehensive view describing the new molecular mechanism associated with miR482/2118 in the plant immune system.

Keywords: MIR482/2118; lncRNA; miR482/2118-3p/5p; phasiRNA; resistance.

Publication types

Review