Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia

Anemut Tilahun; Endeshaw Chekol; Awgchew Behaile Teklemaryam; Melaku Mekonnen Agidew; Zelalem Tilahun; Fitalew Tadele Admassu; Nega Dagnaw; Misganaw Asmamaw Mengstie; Alebachew Amsalu; Enyew Fenta Mengistu; Yibeltal Akelew; Tadesse Asmamaw; Berihun Bantie

doi:10.1016/j.heliyon.2022.e11342

Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia

Heliyon. 2022 Oct 29;8(11):e11342. doi: 10.1016/j.heliyon.2022.e11342. eCollection 2022 Nov.

Affiliations

¹ Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
² Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
³ Department of Biomedical Sciences, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
⁴ Department of Medical Laboratory, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
⁵ Department of Biochemistry, College of Health Sciences, Gondar University, Gondar, Ethiopia.
⁶ Department of Adult Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Abstract

Background: Highly active anti-retroviral therapy has been reported to be associated with a number of side effects in human immunodeficiency virus patients among which dyslipidemia isa common metabolic disorder.

Methods: A Hospital based comparative cross-sectional study among 228 HIV positive patients was conducted from July to August 2020. Socio-demographic and clinical data were collected using structured questionnaires. Fasting venous blood sample was collected and analyzed for Lipid profiles. EDTA sample was analyzed for CD4+ T cell determination. Anthropometric measurement was done. Data were analyzed using SPSS version 22. Independent t-test was done. Logistic and binary regression was done.

Result: A total of 228 HIV patients were enrolled in the study. Prevalence of dyslipidemia in HAART naive and HAART treated patients was 61 (53.5%) and 84 (73.7%), respectively. The prevalence of Total Cholesterol ≥200 mg/dl was 50% and 30%; High density lipoprotein cholesterol <40 mg/dl was 43.8% and 36%; Low density lipoprotein cholesterol ≥130 mg/dl was 48.3% and 28.1%; and Triglyceride ≥ 150 mg/dl 59.6% and 39% among HAART treated and HAART naive, respectively. Age greater than 40 years (AOR = 3.27, 95% C.I: 1.47-7.25), blood pressure ≥140/90 (AOR = 16.13, 95% C.I: 5.81-44.75), being on HAART (AOR = 2.73, 95% C.I: 1.35-5.53) and body mass index >25 kg/m² (AOR = 1.92, 95% C.I: 1.20-4.81) were identified as determinants of dyslipidemia.

Conclusion: The mean value of lipid profile was significantly higher among HAART treated as compared to those HAART naive HIV positive clients.

Keywords: Debre Tabor; Dyslipidemia; Ethiopia; HAART; HIV/AIDS.