Biophysical insights into the binding capability of Cu(II) schiff base complex with BSA protein and cytotoxicity studies against SiHa

Minakshi Maity; Ushasi Pramanik; Venkatesha R Hathwar; Paula Brandao; Saptarshi Mukherjee; Swapan Maity; Ribhu Maity; Tithi Maity; Bidhan Chandra Samanta

doi:10.1016/j.heliyon.2022.e11345

Biophysical insights into the binding capability of Cu(II) schiff base complex with BSA protein and cytotoxicity studies against SiHa

Heliyon. 2022 Nov 2;8(11):e11345. doi: 10.1016/j.heliyon.2022.e11345. eCollection 2022 Nov.

Authors

Minakshi Maity¹, Ushasi Pramanik², Venkatesha R Hathwar³, Paula Brandao⁴, Saptarshi Mukherjee², Swapan Maity⁵, Ribhu Maity¹, Tithi Maity⁶, Bidhan Chandra Samanta¹

Affiliations

¹ Department of Chemistry, Mugberia Gangadhar Mahavidyalaya, Bhupatinagar, Purba Medinipur, 721425, West Bengal, India.
² Department of Chemistry, IISER Bhopal, Bhopal Bypass Road, Bhauri, Bhopal 462 066, Madhya Pradesh, India.
³ School of Physical and Applied Sciences, Goa University, Taleigao Plateau, Goa 403 206, India.
⁴ Departamento de Química/CICECO, Universidade de Aveiro, 3810-193 Aveiro, Portugal.
⁵ School of Materials Science and Technology (SMST), Indian Institute of Technology (IIT), BHU, India.
⁶ Department of Chemistry, Prabhat Kumar College, Purba Medinipur, Contai, 721401, West Bengal, India.

Abstract

Herein, we have explored the effects of chlorinated mononuclear Cu(II) complex upon binding with BSA protein (bovine serum albumin) and its in vitro anti-proliferative potentiality against SiHa cell. The complex was synthesized involving a Schiff base ligand having N,N,O donor centers and characterized by several spectroscopic studies. Structure, DFT studies and Hirshfeld surface (HS) analyses were identified using crystallographic computational studies. The binding interaction with BSA depicts the efficacy of the complex towards promising binding of it with BSA. Further, the complex shows a moderate cytotoxicity against SiHa cancer cell signifying its potentiality as an anti-proliferative agent for human cervix uteri carcinoma.

Keywords: BSA quencher; Cu(II) complex; Cytotoxicity; Schiff base; SiHa cancer cell.