Regulation mechanism of ferroptosis and its research progress in tumor immunotherapy

Jing Xu; Xiaolin Lin; Ting Han; Qingqing Zhou; Yang Su; Shuqing Jiang; Xiuying Xiao; Tengfei Liu

doi:10.3389/fmolb.2022.1045548

Regulation mechanism of ferroptosis and its research progress in tumor immunotherapy

Front Mol Biosci. 2022 Oct 25:9:1045548. doi: 10.3389/fmolb.2022.1045548. eCollection 2022.

Authors

Jing Xu¹, Xiaolin Lin², Ting Han², Qingqing Zhou³, Yang Su⁴, Shuqing Jiang⁴, Xiuying Xiao², Tengfei Liu²

Affiliations

¹ Jining Medical University, Jining, China.
² Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁴ State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Ferroptosis is a novel regulatory cell death, which is characterized by iron dependency and mainly caused by accumulation of intracellular lipid peroxides and reactive oxygen species. Ferroptosis plays an important role in the occurrence and development of a variety of malignant tumors, especially in anti-tumor treatment. As an emerging treatment method, the immunotherapy has been widely applied in the clinical practice, and the role of ferroptosis in tumor immunotherapy has been gradually explored. This study aims to illustrate the features of ferroptosis, and its role in anti-tumor immunotherapy and potential clinical application.

Keywords: anti-tumor immunotherapy; ferroptosis; ferroptosis inducer and inhibitor; metabolic pathway; review.

Publication types

Review