A literature review on the potential clinical implications of streptococci in gastric cancer

Mengli Zi; Yanqiang Zhang; Can Hu; Shengjie Zhang; Jinxia Chen; Li Yuan; Xiangdong Cheng

doi:10.3389/fmicb.2022.1010465

A literature review on the potential clinical implications of streptococci in gastric cancer

Front Microbiol. 2022 Oct 26:13:1010465. doi: 10.3389/fmicb.2022.1010465. eCollection 2022.

Authors

Mengli Zi¹, Yanqiang Zhang^{1

2

3}, Can Hu^{1

2

3}, Shengjie Zhang^{1

2

3}, Jinxia Chen^{1

2

3}, Li Yuan^{1

2

3}, Xiangdong Cheng^{1

2

3}

Affiliations

¹ Department of Gastric surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China.
² Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou, China.
³ Zhejiang Key Lab of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Zhejiang Cancer Hospital, Hangzhou, China.

Abstract

Streptococcus is widely found in nature and the human body, and most species are not pathogenic. In recent years, studies have found that Streptococcus is associated with gastric cancer. Streptococcus was found to be enriched in the oral cavity, stomach and intestine of gastric cancer patients and found to be increased in gastric cancer tissues, suggesting that Streptococcus may be the pathogenic bacteria underlying gastric cancer. This review discusses the discovery of Streptococcus, the relationship between Streptococcus and gastric cancer, and the possible carcinogenic mechanism of Streptococcus and summarizes the progress of the research on the role of Streptococcus in gastric cancer to provide new ideas for the early detection, diagnosis and treatment of gastric cancer.

Keywords: Helicobacter pylori; Streptococcus; digestive tract; gastric cancer; oral.

Publication types

Review