Cortical VIP neurons locally control the gain but globally control the coherence of gamma band rhythms

Julia Veit; Gregory Handy; Daniel P Mossing; Brent Doiron; Hillel Adesnik

doi:10.1016/j.neuron.2022.10.036

Cortical VIP neurons locally control the gain but globally control the coherence of gamma band rhythms

Neuron. 2023 Feb 1;111(3):405-417.e5. doi: 10.1016/j.neuron.2022.10.036. Epub 2022 Nov 15.

Authors

Julia Veit¹, Gregory Handy², Daniel P Mossing³, Brent Doiron², Hillel Adesnik⁴

Affiliations

¹ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. Electronic address: julia.veit@physiologie.uni-freiburg.de.
² Departments of Neurobiology and Statistics, University of Chicago, Chicago, IL, USA; Grossman Center for Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL, USA.
³ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Biophysics Graduate Program, University of California, Berkeley, Berkeley, CA, USA.
⁴ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; The Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA. Electronic address: hadesnik@berkeley.edu.

Abstract

Gamma band synchronization can facilitate local and long-range neural communication. In the primary visual cortex, visual stimulus properties within a specific location determine local synchronization strength, while the match of stimulus properties between distant locations controls long-range synchronization. The neural basis for the differential control of local and global gamma band synchronization is unknown. Combining electrophysiology, optogenetics, and computational modeling, we found that VIP disinhibitory interneurons in mouse cortex linearly scale gamma power locally without changing its stimulus tuning. Conversely, they suppress long-range synchronization when two regions process non-matched stimuli, tuning gamma coherence globally. Modeling shows that like-to-like connectivity across space and specific VIP→SST inhibition capture these opposing effects. VIP neurons thus differentially impact local and global properties of gamma rhythms depending on visual stimulus statistics. They may thereby construct gamma-band filters for spatially extended but continuous image features, such as contours, facilitating the downstream generation of coherent visual percepts.

Keywords: VIP; binding; coherence; gamma; inhibition; neocortex; neural circuit; optogenetics; oscillation; rhythm; synchrony; visual cortex.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Computer Simulation
Cortical Synchronization / physiology
Gamma Rhythm*
Interneurons / physiology
Mice
Neurons / physiology
Visual Cortex* / physiology

Abstract

Publication types

MeSH terms

Grants and funding