Tigliane-and daphnane-type diterpenoids from the buds of Daphne genkwa with their cytotoxic activities

Ying Chen; Cai-Lin Zhao; Wei Dong; Fei-Fan Song; Li-Na Guo; Hong-Lian Zhang; Lv Zhen; Li Li; Jin Ye; Bo Song

doi:10.1080/14786419.2022.2147168

Tigliane-and daphnane-type diterpenoids from the buds of Daphne genkwa with their cytotoxic activities

Nat Prod Res. 2023 Aug-Sep;37(18):3163-3169. doi: 10.1080/14786419.2022.2147168. Epub 2022 Nov 16.

Authors

Ying Chen¹, Cai-Lin Zhao¹, Wei Dong¹, Fei-Fan Song², Li-Na Guo¹, Hong-Lian Zhang¹, Lv Zhen¹, Li Li¹, Jin Ye¹, Bo Song¹

Affiliations

¹ Qiqihar Medical University, Qiqihar, Heilongjiang, PR China.
² Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, PR China.

PMID: 36382781
DOI: 10.1080/14786419.2022.2147168

Abstract

Two new tigliane- and daphnane-type diterpenoids, given the trivial names daphnegens A-B (1-2) were isolated from the buds of Daphne genkwa. Their structures were assigned on the basis of extensive spectroscopic. The absolute configurations of both compounds were determined by comparison of their calculated and experimental CD curves. In addition, compounds 1-2 were tested for their cytotoxic activities against MCF-7 and HepG-2 human cancer cell lines, and compound 2 showed remarkable cytotoxic activity against HepG-2 cell line with the IC₅₀ value of 11.5 μM.

Keywords: Daphne genkwa; cytotoxic activities; daphnane-type diterpenoid; tigliane- type diterpenoid.