Antibodies as drugs-a Keystone Symposia report

Jennifer Cable; Erica Ollmann Saphire; Adrian C Hayday; Timothy D Wiltshire; Jarrod J Mousa; David P Humphreys; Esther C W Breij; Pierre Bruhns; Matteo Broketa; Genta Furuya; Blake M Hauser; Matthieu Mahévas; Andrea Carfi; Tineke Cantaert; Peter D Kwong; Prabhanshu Tripathi; Jonathan H Davis; Neil Brewis; Bruce A Keyt; Felix L Fennemann; Vincent Dussupt; Arvind Sivasubramanian; Philip M Kim; Reda Rawi; Eve Richardson; Daniel Leventhal; Rachael M Wolters; Cecile A W Geuijen; Matthew A Sleeman; Niccolo Pengo; Francesca Rose Donnellan

doi:10.1111/nyas.14915

Antibodies as drugs-a Keystone Symposia report

Ann N Y Acad Sci. 2023 Jan;1519(1):153-166. doi: 10.1111/nyas.14915. Epub 2022 Nov 16.

Authors

Jennifer Cable¹, Erica Ollmann Saphire^{2

3}, Adrian C Hayday^{4

5

6}, Timothy D Wiltshire⁷, Jarrod J Mousa^{8

9

10}, David P Humphreys¹¹, Esther C W Breij¹², Pierre Bruhns¹³, Matteo Broketa¹³, Genta Furuya¹⁴, Blake M Hauser¹⁵, Matthieu Mahévas¹⁶, Andrea Carfi^{17

18}, Tineke Cantaert¹⁹, Peter D Kwong²⁰, Prabhanshu Tripathi²⁰, Jonathan H Davis²¹, Neil Brewis²², Bruce A Keyt²³, Felix L Fennemann²⁴, Vincent Dussupt^{25

26}, Arvind Sivasubramanian²⁷, Philip M Kim^{28

29}, Reda Rawi²⁰, Eve Richardson³⁰, Daniel Leventhal³¹, Rachael M Wolters³², Cecile A W Geuijen³³, Matthew A Sleeman³⁴, Niccolo Pengo³⁵, Francesca Rose Donnellan³⁶

Affiliations

¹ PhD Science Writer, New York, New York, USA.
² Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
³ Department of Medicine, University of California San Diego, La Jolla, California, USA.
⁴ Peter Gorer Department of Immunobiology, King's College London, London, UK.
⁵ Cancer Research UK Cancer Immunotherapy Accelerator, London, UK.
⁶ Immunosurveillance Laboratory, The Francis Crick Institute, London, UK.
⁷ Mayo Clinic, Rochester, Minnesota, USA.
⁸ Department of Infectious Diseases and Center for Vaccines and Immunology, College of Veterinary Medicine, Athens, Georgia, USA.
⁹ Department of Biochemistry and Molecular Biology, Franklin College of Arts and Sciences, University of Georgia, Athens, Georgia, USA.
¹⁰ Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
¹¹ Protein Sciences, UCB Pharma, Berkshire, UK.
¹² Translational Research and Precision Medicine, Genmab BV, Utrecht, the Netherlands.
¹³ Institut Pasteur, Université de Paris, Unit of Antibodies in Therapy and Pathology, Paris, France.
¹⁴ Department of Preventive Medicine and Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
¹⁵ Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
¹⁶ Service de Médecine Interne, Centre de Référence des Cytopénies Auto-immunes de l'adulte, Centre Hospitalier Universitaire Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris-Est Créteil, Créteil, France.
¹⁷ Moderna Inc., Cambridge, Massachusetts, USA.
¹⁸ Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
¹⁹ Immunology Unit, Institut Pasteur du Cambodge, The Pasteur Network, Phnom Penh, Cambodia.
²⁰ Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
²¹ Invenra, Inc, Madison, Wisconsin, USA.
²² F-star Therapeutics Ltd., Cambridge, UK.
²³ IGM Biosciences, Inc., Mountainview, California, USA.
²⁴ Lava Therapeutics, Utrecht, the Netherlands.
²⁵ Emerging Infectious Diseases Branch, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
²⁶ Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
²⁷ Computational Biology, Adimab, Palo Alto, California, USA.
²⁸ Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.
²⁹ Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
³⁰ Department of Statistics, University of Oxford, Oxford, UK.
³¹ Generate Biomedicines, Somerville, Massachusetts, USA.
³² Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
³³ Merus N.V., Utrecht, the Netherlands.
³⁴ Regeneron Pharmaceuticals, Tarrytown, New York, USA.
³⁵ Mabylon AG, Schlieren, Switzerland.
³⁶ University of Oxford, Oxford, UK.

Abstract

Therapeutic antibodies have broad indications across diverse disease states, such as oncology, autoimmune diseases, and infectious diseases. New research continues to identify antibodies with therapeutic potential as well as methods to improve upon endogenous antibodies and to design antibodies de novo. On April 27-30, 2022, experts in antibody research across academia and industry met for the Keystone symposium "Antibodies as Drugs" to present the state-of-the-art in antibody therapeutics, repertoires and deep learning, bispecific antibodies, and engineering.

Keywords: SARS-CoV-2; allergies; antibodies; antibody design; bispecific antibodies; therapeutic antibodies.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Bispecific* / therapeutic use
Humans
Immunotherapy

Substances

Antibodies, Bispecific

Abstract

Publication types

MeSH terms

Substances

Grants and funding