Human Monkeypox in People With HIV: Transmission, Clinical Features, and Outcome

María Jesús Vivancos-Gallego; Matilde Sánchez-Conde; Mario Rodríguez-Domínguez; Pablo Fernandez-Gonzalez; Laura Martínez-García; Emilio Garcia-Mouronte; Javier Martínez-Sanz; Ana María Moreno-Zamora; Jose Luis Casado; Raquel Ron; Juan Carlos Galán; María Jesús Pérez-Elías; Santiago Moreno

doi:10.1093/ofid/ofac557

Human Monkeypox in People With HIV: Transmission, Clinical Features, and Outcome

Open Forum Infect Dis. 2022 Oct 19;9(11):ofac557. doi: 10.1093/ofid/ofac557. eCollection 2022 Nov.

Authors

María Jesús Vivancos-Gallego^{1

2}, Matilde Sánchez-Conde^{1

2}, Mario Rodríguez-Domínguez^{3

4}, Pablo Fernandez-Gonzalez⁵, Laura Martínez-García^{3

4}, Emilio Garcia-Mouronte⁵, Javier Martínez-Sanz^{1

2}, Ana María Moreno-Zamora^{1

2}, Jose Luis Casado^{1

2}, Raquel Ron^{1

2}, Juan Carlos Galán^{3

4}, María Jesús Pérez-Elías^{1

2}, Santiago Moreno^{1

2

6}

Affiliations

¹ Department of Infectious Diseases, University Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.
² CIBERINFEC, Madrid, Spain.
³ Department of Microbiology, University Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.
⁴ CIBERESP, Madrid, Spain.
⁵ Department of Dermatology, University Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.
⁶ Alcalá University, Madrid, Spain.

Abstract

We describe the first 25 persons with HIV diagnosed with human monkeypox virus (MPXV) in our hospital in an ongoing outbreak in Spain. Proctitis was the predominant finding in 52%, and MPXV DNA was detected in rectal swabs from 90%. Proctitis and demonstration of MPXV in rectal swabs support the sexual transmission of MPXV.

Keywords: HIV; clinical characteristics; human monkeypox; outcome; sexually transmitted infections; transmission.