Design, development, and local production of lipid-based nutritional supplements to enhance the complementary feeding diet: A model for collaboration for a feeding trial in Bangladesh

Gates Open Res. 2022 Sep 21:6:122. doi: 10.12688/gatesopenres.13673.1. eCollection 2022.

Abstract

Background: Lipid-based nutrient supplements (LNS) are effective for treating childhood wasting and for preventing stunting, wasting, and anemia, but large-scale production and programmatic use are a barrier. Locally-developed and produced LNS may be more affordable and reduce logistical procurement and importation hurdles, while promoting private sector engagement and partnership. Methods: In northwestern Bangladesh, we conducted a community-based trial of complementary food supplementation to test its efficacy to reduce childhood stunting. Two locally-developed, small-quantity LNS (20g/day, rice-lentil and chick-pea based) were designed, developed first at small scale in the 'kitchen' laboratory under controlled conditions, followed by taking them to a local food manufacturer for larger production for the study. We describe here the partnership, required expertise and capacity, experiences, and lessons learned that made this uniquely complex undertaking possible Results: Key steps in the journey included addressing the dynamics of clear communication between partners, executing on carefully assigned tasks and roles, correcting course when needed, and maintaining timeliness and roadmaps. Knowledge of food science and technology was key in solving many food-production challenges that were encountered in taking the laboratory recipe to the factory. Factory production was established and had to meet quality and hygiene criteria set for young children. Conclusions: We provide documentation of this experience as a model to describe the various steps and considerations and what is entailed in local LNS production. We highlight the importance of a well-conceived collaboration with clear roles that created a 'win-win' situation for all partners for achieving common goals, establishing improved technology at the factory, and building new capacity to produce such products for children in a low resource setting. Key words: micronutrient, lipid-based nutrient supplements, maternal and child, malnutrition, multiagency collaboration.

Keywords: lipid-based nutrient supplements; malnutrition; maternal and child; micronutrient; multiagency collaboration.

Grants and funding

This work was supported by the Bill and Melinda Gates Foundation [OPP1141435] and the United States Department of Agriculture, National Institute of Food and Agriculture (NIFA) under the Food and Nutrition Enhancement Program [Award No. 2010-38418-21732]. In-kind support in the form of micronutrient premix for the food supplements was provided by DSM (Kaiseraugst, Switzerland) and Plumpy’doz was provided by Nutriset (Maulany, France). Additional support for the study was provided by the Johns Hopkins Sight and Life Research Institute. Olympic Industries Ltd, Dhaka is acknowledged for their partnership in manufacturing the foods for the study.