Epigenetic alterations fuel brain metastasis via regulating inflammatory cascade

Shailendra Kumar Maurya; Asad Ur Rehman; Mohd Ali Abbas Zaidi; Parvez Khan; Shailendra K Gautam; Juan A Santamaria-Barria; Jawed Akhtar Siddiqui; Surinder K Batra; Mohd Wasim Nasser

doi:10.1016/j.semcdb.2022.11.001

Epigenetic alterations fuel brain metastasis via regulating inflammatory cascade

Semin Cell Dev Biol. 2024 Feb 15;154(Pt C):261-274. doi: 10.1016/j.semcdb.2022.11.001. Epub 2022 Nov 12.

Authors

Shailendra Kumar Maurya¹, Asad Ur Rehman¹, Mohd Ali Abbas Zaidi¹, Parvez Khan¹, Shailendra K Gautam¹, Juan A Santamaria-Barria², Jawed Akhtar Siddiqui³, Surinder K Batra⁴, Mohd Wasim Nasser⁵

Affiliations

¹ Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68108, USA.
² Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68108, USA.
³ Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68108, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68108, USA.
⁴ Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68108, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68108, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
⁵ Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68108, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68108, USA. Electronic address: wasim.nasser@unmc.edu.

PMID: 36379848
PMCID: PMC10198579 (available on 2025-02-15)
DOI: 10.1016/j.semcdb.2022.11.001

Abstract

Brain metastasis (BrM) is a major threat to the survival of melanoma, breast, and lung cancer patients. Circulating tumor cells (CTCs) cross the blood-brain barrier (BBB) and sustain in the brain microenvironment. Genetic mutations and epigenetic modifications have been found to be critical in controlling key aspects of cancer metastasis. Metastasizing cells confront inflammation and gradually adapt in the unique brain microenvironment. Currently, it is one of the major areas that has gained momentum. Researchers are interested in the factors that modulate neuroinflammation during BrM. We review here various epigenetic factors and mechanisms modulating neuroinflammation and how this helps CTCs to adapt and survive in the brain microenvironment. Since epigenetic changes could be modulated by targeting enzymes such as histone/DNA methyltransferase, deacetylases, acetyltransferases, and demethylases, we also summarize our current understanding of potential drugs targeting various aspects of epigenetic regulation in BrM.

Keywords: Brain metastasis; Brain microenvironment; Epigenetics regulation; Inflammation; Inflammatory cascade.

Publication types

Review

MeSH terms

Brain Neoplasms* / genetics
Epigenesis, Genetic
Humans
Inflammation / genetics
Lung Neoplasms*
Neuroinflammatory Diseases
Tumor Microenvironment / genetics

Abstract

Publication types

MeSH terms

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