Laboratory Perspective of Concurrent Acute Myeloid Leukemia and COVID-19: a Case Report and Review of Literature

Clin Lab. 2022 Nov 1;68(11). doi: 10.7754/Clin.Lab.2022.220144.

Abstract

Background: Whether the diagnosis and treatment of coronavirus disease 2019 (COVID-19) affect the clinical course of patients with hematologic malignancies has been of interest during the COVID-19 pandemic.

Methods: We describe a 47-year-old female who was concurrently diagnosed with COVID-19 and acute myeloid leukemia (AML).

Results: She developed COVID-19 pneumonia which required treatment with remdesivir and dexamethasone, and induction therapy for t-AML was delayed. After her COVID-19 was resolved and isolation ended, follow-up bone marrow examination showed decreased leukemic burden.

Conclusions: This case describes possible effects of COVID-19 treatment on the clinical course of patients with AML from a laboratory perspective.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Bone Marrow / pathology
  • COVID-19 Drug Treatment
  • COVID-19*
  • Female
  • Humans
  • Leukemia, Myeloid, Acute* / complications
  • Leukemia, Myeloid, Acute* / diagnosis
  • Leukemia, Myeloid, Acute* / drug therapy
  • Middle Aged
  • Pandemics