Elevated soluble urokinase plasminogen activator receptor is associated with renal dysfunction in a Chlorocebus atheiops COVID-19 model

J Med Primatol. 2023 Apr;52(2):131-134. doi: 10.1111/jmp.12626. Epub 2022 Nov 15.

Abstract

Increases of soluble urokinase plasminogen activator receptor (suPAR) were measured in both urine and plasma of a Chlorocebus aethiops (African green monkey; AGM) mucosal infected with SARS-CoV-2. The data indicate that elevated suPAR may be associated with renal dysfunction and pathology in the context of COVID-19.

Keywords: African green monkey; SARS-CoV-2; acute kidney injury; nonhuman primate; renal injury.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Biomarkers
  • COVID-19* / complications
  • Chlorocebus aethiops
  • Kidney Diseases*
  • Receptors, Urokinase Plasminogen Activator
  • SARS-CoV-2

Substances

  • Receptors, Urokinase Plasminogen Activator
  • Biomarkers