Pathogenesis and histological changes of nephropathy associated with COVID-19

Lirong Lin; Junhui Deng; Wei Tan; Jie Li; Zhifeng Wu; Luquan Zheng; Jurong Yang

doi:10.1002/jmv.28311

Pathogenesis and histological changes of nephropathy associated with COVID-19

J Med Virol. 2023 Jan;95(1):e28311. doi: 10.1002/jmv.28311.

Authors

Lirong Lin¹, Junhui Deng¹, Wei Tan¹, Jie Li², Zhifeng Wu¹, Luquan Zheng¹, Jurong Yang¹

Affiliations

¹ Department of Nephrology, The Third Affiliated Hospital of Chongqing Medical University (Gener Hospital), Chongqing, China.
² Department of Nephrology, Yongchuan People's Hospital of Chongqing, Chongqing, China.

PMID: 36377540
DOI: 10.1002/jmv.28311

Abstract

Coronavirus disease 2019 (COVID-19) can cause damage to multiple organ, not only to the lungs, but also to the kidneys. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute and chronic kidney disease through direct viral infection, indirect injury, and vaccination-related injury. Like lung injury, kidney injury is also an important aspect affecting the severity and prognosis of SARS-CoV-2. This article summarizes the pathogenesis, pathological manifestations, and clinical features of SARS-CoV-2 direct or indirect renal injury. Including direct injury, indirect injury, special comorbidities (receiving kidney transplantation and chronic kidney disease), and vaccine-related renal injury, and exploring the possible therapeutic effect of anti-SARS-CoV-2 therapy on renal injury. The purpose is to provide reference for understanding COVID-19-related renal injury, guiding clinical and pathological diagnosis and treatment, and evaluating prognosis.

Keywords: COVID-19; SARS-CoV-2; histological; kidney injury.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acute Kidney Injury* / etiology
Acute Kidney Injury* / therapy
COVID-19* / complications
Humans
Kidney
Renal Insufficiency, Chronic* / complications
SARS-CoV-2