The crosstalk between intestinal bacterial microbiota and immune cells in colorectal cancer progression

Clin Transl Oncol. 2023 Mar;25(3):620-632. doi: 10.1007/s12094-022-02995-5. Epub 2022 Nov 14.

Abstract

Different types of cells that are involved in tumor immunity play a significant part in antitumor therapy. The intestinal microbiota consist of the trillions of diverse microorganisms that inhabit the gastrointestinal tract. Recently, much emphasis has been paid to the link between these symbionts and colorectal cancer (CRC). This association might be anything from oncogenesis and cancer development to resistance or susceptibility to chemotherapeutic medicines. Cancer patients have a significantly different microbial composition in their guts compared to healthy persons. The microbiome may play a role in the development and development of cancer through the modulation of tumor immunosurveillance, as shown by these studies; however, the specific processes underlying this role are still poorly understood. This review focuses on the relationship between the intestinal bacterial microbiota and immune cells to determine how the commensal microbiome influences the initiation and development of CRC.

Keywords: Colorectal cancer; Dysbiosis; Immune cells; Microbiota.

Publication types

  • Review

MeSH terms

  • Bacteria
  • Colorectal Neoplasms*
  • Gastrointestinal Microbiome*
  • Humans
  • Microbiota*