The role of mitochondrial fission in intervertebral disc degeneration

Z Lin; H Wang; J Song; G Xu; F Lu; X Ma; X Xia; J Jiang; F Zou

doi:10.1016/j.joca.2022.10.020

The role of mitochondrial fission in intervertebral disc degeneration

Osteoarthritis Cartilage. 2023 Feb;31(2):158-166. doi: 10.1016/j.joca.2022.10.020. Epub 2022 Nov 12.

Authors

Z Lin¹, H Wang², J Song³, G Xu⁴, F Lu⁵, X Ma⁶, X Xia⁷, J Jiang⁸, F Zou⁹

Affiliations

¹ Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: drzdlin@126.com.
² Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: wanghongli@huashan.org.cn.
³ Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: jsong16@fudan.edu.cn.
⁴ Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: xuguangyuhs@126.com.
⁵ Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: lufeizhou@hotmail.com.
⁶ Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: mxshs893@126.com.
⁷ Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: xinleixiaspine@126.com.
⁸ Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: jjy@fudanspine.com.
⁹ Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: zoufei@huashan.org.cn.

PMID: 36375758
DOI: 10.1016/j.joca.2022.10.020

Abstract

Low back pain (LBP) is an extremely common disorder and is a major cause of disability globally. Intervertebral disc degeneration (IVDD) is the main contributor to LBP. Nevertheless, the specific mechanisms underlying the pathogenesis of IVDD remain unclear. Mitochondria are highly dynamic organelles that continuously undergo fusion and fission, known as mitochondrial dynamics. Accumulating evidence has revealed that aberrantly activated mitochondrial fission leads to mitochondrial fragmentation and dysfunction, which are involved in the development and progression of IVDD. To date, research into mitochondrial dynamics in IVDD is at an early stage. The present narrative review aims to summarize the most recent findings about the role of mitochondrial fission in the pathogenesis of IVDD.

Keywords: Drp1; Intervertebral disc degeneration; Mitochondrial dysfunction; Mitochondrial fission.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Intervertebral Disc Degeneration* / pathology
Intervertebral Disc* / pathology
Low Back Pain* / etiology
Mitochondria / pathology
Mitochondrial Dynamics