[Role of β2-Adrenergic Receptor Agonist in the Cognitive Impairment Associated with Neurodegenerative Diseases]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Dec;44(6):1112-1116. doi: 10.3881/j.issn.1000-503X.14469.
[Article in Chinese]

Abstract

Studies have revealed the neuropathological mechanism of the cognitive impairment associated with neurodegenerative diseases.However,the therapies for these cognitive disorders are limited,and the prevalence of cognitive impairment is expected to increase significantly in the future,which proves the necessity of new therapeutic agents.In recent years,the pharmacological activity of β2-adrenergic receptor(β2-AR)has been extensively studied,which has demonstrated that β2-AR agonist has therapeutic effects on the cognitive impairment associated with several common neurodegenerative diseases,including Alzheimer's disease,vascular dementia,Parkinson's disease with dementia,and Lewy body dementia.We reviewed the neuropathological features of cognitive impairment in several common neurodegenerative diseases and expounded the pharmacological effects of β2-AR on related diseases.

Keywords: cognitive disorders; neurodegenerative diseases; neuropathology; treatment; β2-adrenergic receptor.

Publication types

  • Review
  • English Abstract

MeSH terms

  • Adrenergic Agonists
  • Alzheimer Disease*
  • Cognitive Dysfunction* / complications
  • Cognitive Dysfunction* / drug therapy
  • Humans
  • Lewy Body Disease* / complications
  • Lewy Body Disease* / drug therapy
  • Lewy Body Disease* / pathology
  • Neurodegenerative Diseases* / complications
  • Neurodegenerative Diseases* / drug therapy

Substances

  • Adrenergic Agonists