Current State of 44Ti/44Sc Radionuclide Generator Systems and Separation Chemistry

Christine E Schmidt; Leah Gajecki; Melissa A Deri; Vanessa A Sanders

doi:10.2174/1874471016666221111154424

Current State of ⁴⁴Ti/⁴⁴Sc Radionuclide Generator Systems and Separation Chemistry

Curr Radiopharm. 2023;16(2):95-106. doi: 10.2174/1874471016666221111154424.

Authors

Christine E Schmidt^{1

2}, Leah Gajecki³, Melissa A Deri^{1

2}, Vanessa A Sanders³

Affiliations

¹ Department of Chemistry, Graduate Center of the City University of New York, New York, NY 10016, USA.
² Department of Chemistry, Lehman College of the City University of New York, New York 10468, USA.
³ Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY 11973, USA.

Abstract

In recent years, there has been an increased interest in ⁴⁴Ti/⁴⁴Sc generators as an onsite source of ⁴⁴Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of ⁴⁴Sc make it a viable candidate for positron emission tomography (PET) imaging. This review discusses current ⁴⁴Ti/⁴⁴Sc generator designs, focusing on their chemistry, drawbacks, post-elution processing, and relevant preclinical studies of the ⁴⁴Sc for potential PET radiopharmaceuticals.

Keywords: PET; Scandium; diagnostics; generators; radioisotope production; radiolabeling; titanium.

Publication types

Review

MeSH terms

Positron-Emission Tomography / methods
Radioisotopes*
Radionuclide Generators
Radiopharmaceuticals*
Scandium
Titanium

Substances

Radioisotopes
Radiopharmaceuticals
Titanium
Scandium

Abstract

Publication types

MeSH terms

Substances

Grants and funding