Advances in green bioproduction of marine and glycosaminoglycan oligosaccharides

Chen Deng; Mengxuan Zhao; Qiong Zhao; Liming Zhao

doi:10.1016/j.carbpol.2022.120254

Advances in green bioproduction of marine and glycosaminoglycan oligosaccharides

Carbohydr Polym. 2023 Jan 15:300:120254. doi: 10.1016/j.carbpol.2022.120254. Epub 2022 Oct 24.

Authors

Chen Deng¹, Mengxuan Zhao¹, Qiong Zhao¹, Liming Zhao²

Affiliations

¹ State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China; Shanghai Collaborative Innovation Center for Biomanufacturing Technology (SCICBT), Shanghai 200237, China.
² State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China; Shanghai Collaborative Innovation Center for Biomanufacturing Technology (SCICBT), Shanghai 200237, China; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China. Electronic address: zhaoliming@ecust.edu.cn.

PMID: 36372511
DOI: 10.1016/j.carbpol.2022.120254

Abstract

Functional oligosaccharides are a class of low-polymerization sugars with physiological functions, showing great potential in the fields of food, medicine, and agriculture, with economic and social value. Certain functional oligosaccharides (e.g., marine oligosaccharides and glycosaminoglycan oligosaccharides) are mainly prepared by degradation of natural polysaccharides using physical and chemical methods. These strategies present problems, including harsh reaction conditions, serious pollution, and variations in product quality. Recently, specific techniques have been applied to the green production of functional oligosaccharides. In this paper, the classification and biological effects of marine oligosaccharides and glycosaminoglycan oligosaccharides are firstly introduced. Then, recent research progress and related databases for green biological preparation of marine oligosaccharides and glycosaminoglycan oligosaccharides are reviewed, and optimization strategies for green bioproduction are summarized. Finally, the limitations and prospects of the current green synthesis strategies are discussed.

Keywords: Activity and application; Enzyme engineering; Functional oligosaccharide; Green biosynthesis; Synthetic biology.

Publication types

Review

MeSH terms

Glycosaminoglycans*
Oligosaccharides* / metabolism
Polysaccharides

Substances

Glycosaminoglycans
Oligosaccharides
Polysaccharides