A chitosan derivative-crosslinked hydrogel with controllable release of polydeoxyribonucleotides for wound treatment

Yanzhen Sun; Xiaodong Jing; Yang Liu; Bing Yu; Hao Hu; Hailin Cong; Youqing Shen

doi:10.1016/j.carbpol.2022.120298

A chitosan derivative-crosslinked hydrogel with controllable release of polydeoxyribonucleotides for wound treatment

Carbohydr Polym. 2023 Jan 15:300:120298. doi: 10.1016/j.carbpol.2022.120298. Epub 2022 Nov 3.

Authors

Yanzhen Sun¹, Xiaodong Jing¹, Yang Liu¹, Bing Yu², Hao Hu³, Hailin Cong⁴, Youqing Shen⁵

Affiliations

¹ Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.
² Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China; Laboratory for New Fiber Materials and Modern Textile, Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China.
³ Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. Electronic address: huhao@qdu.edu.cn.
⁴ Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China; Laboratory for New Fiber Materials and Modern Textile, Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China; School of Materials Science and Engineering, Shandong University of Technology, Zibo 255000, China. Electronic address: conghailin@qdu.edu.cn.
⁵ Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China; Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

PMID: 36372498
DOI: 10.1016/j.carbpol.2022.120298

Abstract

Nucleic acid-based agents have advantages in therapeutic efficacy and biological safety. However, due to its facile degradability, it lacks an effective route of administration in wound treatment. Designing smart hydrogels for the spatiotemporally controllable delivery of nucleic acids is of great significance for clinical applications. Here, a near-infrared (NIR)-responsive nanocomposite hydrogel was prepared using methyl methacrylate (GMA)-modified chitosan as the macromolecular cross-linker, N-isopropylacrylamide (NIPAAm) as the backbone, and molybdenum disulfide nanosheets (MoS₂ NSs) as the nanocomponents. The polydeoxyribonucleotide (PDRN), a nucleic acid-based agent that promotes tissue regeneration, was loaded and delivered. The photothermal conversion capability of MoS₂ NSs enables customized care of PDRNs and antibacterial enhancement. In a full-thickness skin defect model, high-quality wound healing effects were demonstrated under the action of nanocomposite hydrogels. The proposed nanocomposite hydrogel provides a new reference for local delivery of nucleic acid-based agents.

Keywords: Drug delivery; Gene therapy; Nanocomposite hydrogel; PDRN; Wound dressing.

MeSH terms

Anti-Bacterial Agents
Chitosan*
Hydrogels
Molybdenum
Nanogels
Nucleic Acids*
Polydeoxyribonucleotides

Substances

Hydrogels
Chitosan
Molybdenum
Polydeoxyribonucleotides
Nanogels
Anti-Bacterial Agents
Nucleic Acids