The state-of-the-art application of functional bacterial cellulose-based materials in biomedical fields

Hanqi Qian; Jingjing Liu; Xucai Wang; Wenhui Pei; Caili Fu; Mingguo Ma; Caoxing Huang

doi:10.1016/j.carbpol.2022.120252

The state-of-the-art application of functional bacterial cellulose-based materials in biomedical fields

Carbohydr Polym. 2023 Jan 15:300:120252. doi: 10.1016/j.carbpol.2022.120252. Epub 2022 Oct 24.

Authors

Hanqi Qian¹, Jingjing Liu², Xucai Wang³, Wenhui Pei³, Caili Fu⁴, Mingguo Ma⁵, Caoxing Huang⁶

Affiliations

¹ Department of Food Science and Technology, Science Drive 2, Faculty of Science, National University of Singapore, Singapore 117542, Singapore.
² School of Life Science and Technology, the Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
³ Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
⁴ National University of Singapore (Suzhou) Research Institute, 377 Lin Quan Street, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China.
⁵ Beijing Key Laboratory of Lignocellulosic Chemistry, College of Materials Science and Technology, Beijing Forestry University, Beijing 100083, China. Electronic address: mg_ma@bjfu.edu.cn.
⁶ Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: hcx@njfu.edu.cn.

PMID: 36372483
DOI: 10.1016/j.carbpol.2022.120252

Abstract

Bacterial cellulose (BC) is a significant polysaccharide that bacteria create under specific growth conditions that exhibits high purity, high water-holding capacity, high crystallinity, strong mechanical capabilities, and high biocompatibility. Pure BC has been studied, marketed, and frequently combined with other materials to provide additional potential effects. Additionally, because of the abundance of hydroxyl groups in BC, it can be readily changed to yield derivatives or composites with improved physicochemical and functional characteristics for a variety of applications such as artificial blood vessel manufacturing, soft tissue engineering, and bone tissue engineering. In this review, state-of-the-art manufacturing, structural traits, and applications of BC are summarized, along with in situ and ex situ modification techniques and their biomedical applications. Finally, the future growth opportunities and obstacles for BC and its composites in the biological sector are anticipated.

Keywords: Bacterial cellulose; Biomaterial; Biomedical applications; Modification strategies.

Publication types

Review

MeSH terms

Bacteria / chemistry
Biocompatible Materials / chemistry
Cellulose* / chemistry
Tissue Engineering*

Substances

Cellulose
Biocompatible Materials