P2X7-dependent immune pathways in retinal diseases

Paul-Alexandre Déchelle-Marquet; Xavier Guillonneau; Florian Sennlaub; Cécile Delarasse

doi:10.1016/j.neuropharm.2022.109332

P2X7-dependent immune pathways in retinal diseases

Neuropharmacology. 2023 Feb 1:223:109332. doi: 10.1016/j.neuropharm.2022.109332. Epub 2022 Nov 11.

Authors

Paul-Alexandre Déchelle-Marquet¹, Xavier Guillonneau¹, Florian Sennlaub¹, Cécile Delarasse²

Affiliations

¹ Sorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France.
² Sorbonne University, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France. Electronic address: cecile.delarasse@inserm.fr.

PMID: 36372269
DOI: 10.1016/j.neuropharm.2022.109332

Abstract

Adenosine triphosphate (ATP) is a signalling molecule acting as a neurotransmitter but also as a danger signal. The purinergic receptor P2X7 is the main sensor of high concentration of ATP released by damaged cells. In the eye, P2X7 is expressed by resident microglia and immune cells that infiltrate the retina in disease such as age-related macular degeneration (AMD), a degenerative retinal disease, and uveitis, an inflammatory eye disease. Activation of P2X7 is involved in several physiological and pathological processes: phagocytosis, activation of the inflammasome NLRP3, release of pro-inflammatory mediators and cell death. The aim of this review is to discuss the potential involvement of P2X7 in the development of AMD and uveitis.

Keywords: Age-related macular degeneration; Macrophage; Microglia; P2X7; Retina; Uveitis.

Publication types

Review

MeSH terms

Adenosine Triphosphate / metabolism
Humans
Macular Degeneration* / metabolism
Phagocytosis
Receptors, Purinergic P2X7 / metabolism
Retina / metabolism
Retinal Diseases* / metabolism
Retinal Diseases* / pathology

Substances

Adenosine Triphosphate
Receptors, Purinergic P2X7