Advancements in the characterization of tissue resident memory T cells in skin disease

Lei Li; PanPan Liu; Chao Chen; Bei Yan; Xiang Chen; Jie Li; Cong Peng

doi:10.1016/j.clim.2022.109183

Advancements in the characterization of tissue resident memory T cells in skin disease

Clin Immunol. 2022 Dec:245:109183. doi: 10.1016/j.clim.2022.109183. Epub 2022 Nov 10.

Authors

Lei Li¹, PanPan Liu¹, Chao Chen¹, Bei Yan¹, Xiang Chen¹, Jie Li¹, Cong Peng²

Affiliations

¹ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China.
² Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China. Electronic address: pengcongxy@csu.edu.cn.

PMID: 36371067
DOI: 10.1016/j.clim.2022.109183

Abstract

The newly discovered subset of memory T cells, tissue resident memory T (TRM) cells, reside in peripheral tissues for a long time, contributing to a rapid immune response and constituting the first line of defense when pathogens invade cells. Tissue resident memory T cells have unique transcriptome characteristics, and their presence in peripheral tissues is regulated by many factors. TRM cells residing in different tissues often express different surface markers. In addition to CD8+ and CD4+ T cells, which are the best-characterized T cells, Treg cells and various innate T cells can reside in nonlymphoid tissues. Many recent studies have shown that tissue resident memory T cells play indispensable roles in tumor immunity and allergic diseases. This paper reviews the differentiation, regulation, variety and function of TRM cells and the roles they play in skin diseases, including cutaneous melanoma and psoriasis.

Keywords: Autoimmune skin diseases; Melanoma; Psoriasis; Tissue resident memory T cells; Tumor immunity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Humans
Immunologic Memory
Melanoma*
Memory T Cells
Skin Neoplasms*