The 10-item LURN Symptom Index (LURN SI-10) Detects Additional Symptoms and Shows Convergent Validity With the IPSS in Men Presenting With Lower Urinary Tract Symptoms

Alexander P Glaser; Tanya W Kristof; Clark Judge; George Javitch; Shira Hirsch; Pooja Talaty; Brian T Helfand; Abigail R Smith; James W Griffith

doi:10.1016/j.urology.2022.10.019

The 10-item LURN Symptom Index (LURN SI-10) Detects Additional Symptoms and Shows Convergent Validity With the IPSS in Men Presenting With Lower Urinary Tract Symptoms

Urology. 2023 Jan:171:184-189. doi: 10.1016/j.urology.2022.10.019. Epub 2022 Nov 9.

Authors

Alexander P Glaser¹, Tanya W Kristof², Clark Judge², George Javitch³, Shira Hirsch³, Pooja Talaty³, Brian T Helfand³, Abigail R Smith⁴, James W Griffith⁵

Affiliations

¹ Department of Surgery, Division of Urology, NorthShore University HealthSystem, Evanston, IL. Electronic address: aglaser@northshore.org.
² Department of Surgery, Section of Urology, University of Chicago Pritzker School of Medicine, Chicago, IL.
³ Department of Surgery, Division of Urology, NorthShore University HealthSystem, Evanston, IL.
⁴ Arbor Research Collaborative for Health, Ann Arbor, MI.
⁵ Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL.

PMID: 36370771
DOI: 10.1016/j.urology.2022.10.019

Abstract

Objective: To determine how the LURN-SI-10, a novel questionnaire developed by the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN), compares with the International Prostate Symptom Score (IPSS) in men with lower urinary tract symptoms (LUTS) attributed to benign prostatic hyperplasia (BPH). Specifically, to assess convergent validity and determine how frequently the LURN-SI-10 identifies symptoms not captured by the IPSS.

Materials and methods: Men presenting with BPH/LUTS were prospectively administered LURN-SI-10 and IPSS questionnaires. Urinary incontinence (UI) including post-void dribbling (PVD), urgency urinary incontinence (UUI), stress urinary incontinence (SUI), as well as bladder pain were considered present if the patient reported "about half the time or more" on LURN-SI-10. Correlations between LURN-SI-10 and IPSS were assessed as continuous and categorical variables. Multivariable linear regression analysis was performed to determine associations with symptom scores.

Results: LURN-SI-10 and IPSS were highly correlated in men with BPH/LUTS (r = 0.82, n = 429), as were respective bother and quality of life scores (ρ = 0.74). The LURN-SI-10 identified additional symptoms including PVD (24%), UUI (13%), SUI (2%), and pain (8%). Men with any UUI, SUI, or PVD had on average a 7.6-point higher LURN-SI-10 score than those without UI (P<.001) and 8.0-point higher IPSS score than those without UI (P<.001).

Conclusion: The LURN-SI-10 correlates strongly with the IPSS, but the LURN-SI-10 identifies additional important symptomatology in men with LUTS. This additional information may improve the evaluation and treatment of men with BPH/LUTS. Further prospective studies of the LURN-SI-10 is warranted.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Lower Urinary Tract Symptoms* / complications
Lower Urinary Tract Symptoms* / etiology
Male
Pain
Prospective Studies
Prostatic Hyperplasia* / complications
Prostatic Hyperplasia* / diagnosis
Quality of Life
Urinary Incontinence* / diagnosis