The role of mechanosensor Piezo1 in bone homeostasis and mechanobiology

Jiao Wang; Yong-Xin Sun; Jiliang Li

doi:10.1016/j.ydbio.2022.11.002

The role of mechanosensor Piezo1 in bone homeostasis and mechanobiology

Dev Biol. 2023 Jan:493:80-88. doi: 10.1016/j.ydbio.2022.11.002. Epub 2022 Nov 8.

Authors

Jiao Wang¹, Yong-Xin Sun², Jiliang Li³

Affiliations

¹ Department of Anesthesiology, The First Affiliated Hospital of China Medical University, NO.155 Nanjing North Street, Shenyang City, Liaoning Province, 110000, China. Electronic address: wangjiao9210@163.com.
² Department of Rehabilitation, The First Affiliated Hospital of China Medical University, NO.155 Nanjing North Street, Shenyang City, Liaoning Province, 110000, China. Electronic address: sunyongxincmu@126.com.
³ Department of Biology, Indiana University Purdue University Indianapolis, 723 West Michigan Street, SL 306, Indianapolis, IN, 46202, USA. Electronic address: jilili@iu.edu.

PMID: 36368521
DOI: 10.1016/j.ydbio.2022.11.002

Abstract

Bones and articular cartilage are important load-bearing tissues. The fluid flow inside the bone cells and cell interaction with the extracellular matrix serve as the mechanical cues for bones and joints. Piezo1 is an ion channel found on the cell surface of many cell types, including osteocytes and chondrocytes. It is activated in response to mechanical stimulation, which subsequently mediates a variety of signaling pathways in osteoblasts, osteocytes, and chondrocytes. Piezo1 activation in osteoblastic cells positively regulates osteogenesis, while its activation in joints mediates cartilage degradation. This review focuses on the most recent research on Piezo1 in bone development and regeneration.

Keywords: Bone; Cartilage; Fluid shear stress; Mechanical loading; Piezo1.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biophysics
Bone and Bones*
Chondrocytes* / physiology
Homeostasis
Stress, Mechanical