The fusion of autophagosomes with endocytic compartments to form amphisomes has only been described in metazoans. In this issue, Zhao et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203139) demonstrate the existence of amphisomes in the plant cell and identify a plant-specific adaptor protein, CFS1, that mediates their biogenesis.
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