Synthesis of imidazo[1,2- a]benzoazepines by alkyne-carbonyl-metathesis

Org Biomol Chem. 2022 Nov 30;20(46):9207-9216. doi: 10.1039/d2ob01320g.

Abstract

Imidazo[1,2-a]benzoazepines were prepared by Brønsted acid-mediated intramolecular alkyne-carbonyl metathesis (ACM). The starting materials, imidazole and benzimidazole derivatives, were prepared by N-alkylation, formylation and Sonogashira cross-coupling reaction. The final intramolecular ACM delivered the final products in good to excellent yields and with a wide tolerance towards functional groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes*
  • Catalysis
  • Cyclization

Substances

  • Alkynes