Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial Therapy

Evelyne Van den Broucke; Lore Thijs; Stefanie Desmet; Lotte Vander Elst; Matthias Gijsen; Marnix Mylemans; Otto Van de Gaer; Willy E Peetermans; Charlotte Quintens; Isabel Spriet

doi:10.3390/pharmaceutics14112289

Clinical Efficacy of Temocillin Standard Dosing in Patients Treated with Outpatient Antimicrobial Therapy

Pharmaceutics. 2022 Oct 25;14(11):2289. doi: 10.3390/pharmaceutics14112289.

Authors

Affiliations

¹ Pharmacy Department, University Hospitals Leuven, 3000 Leuven, Belgium.
² Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
³ Clinical Department of Laboratory Medicine, University Hospitals Leuven, 3000 Leuven, Belgium.
⁴ Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
⁵ Department of General Internal Medicine, University Hospitals Leuven, 3000 Leuven, Belgium.

Abstract

In 2020, EUCAST introduced breakpoints for temocillin. Based on these guidelines, reporting of temocillin susceptibility of Enterobacterales in the context of complicated urinary tract infections (cUTI) implicates the use of a high dose of temocillin (2 g q8h) constantly. We aimed to evaluate the clinical outcome of patients treated with the standard dose (4 g/day) of temocillin in outpatient parenteral antimicrobial therapy (tOPAT). Demographics, clinical and treatment parameters, and late clinical cure (at day 30 after tOPAT completion) were recorded. Univariate generalised estimating equation analyses, with clinical cure as outcome variable, were performed to evaluate covariate associations. Fifty-seven tOPAT episodes in 50 patients were included with a median antimicrobial treatment duration of 21 (range 10-228) days, and cUTI was the main indication (87.7%). Late clinical cure was achieved in 85.7% of the tOPAT episodes. Non-disseminated infections and minimal inhibitory concentrations (MIC) values ≤ 8 mg/L were associated with good late clinical outcome. In conclusion, a standard temocillin dose (4 g/day) results in good clinical outcomes in the treatment of cUTIs in tOPAT patients. Therefore, our centre concluded that the use of standard temocillin dosing should be continued instead of the high dose for cUTI in non-critically ill patients infected with Enterobacterales with an MIC ≤ 4 mg/L.

Keywords: EUCAST; MIC; OPAT at home; dosing; temocillin.

Grants and funding

This research received no external funding by agencies in the public, commercial, or not-for-profit sectors. IS is supported by the Clinical Research Fund of the University Hospitals Leuven. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.