Recent Research and Application Prospect of Functional Oligosaccharides on Intestinal Disease Treatment

Molecules. 2022 Nov 7;27(21):7622. doi: 10.3390/molecules27217622.

Abstract

The intestinal tract is an essential digestive organ of the human body, and damage to the intestinal barrier will lead to various diseases. Functional oligosaccharides are carbohydrates with a low degree of polymerization and exhibit beneficial effects on human intestinal health. Laboratory experiments and clinical studies indicate that functional oligosaccharides repair the damaged intestinal tract and maintain intestinal homeostasis by regulating intestinal barrier function, immune response, and intestinal microbial composition. Functional oligosaccharides treat intestinal disease such as inflammatory bowel disease (IBD) and colorectal cancer (CRC) and have excellent prospects for therapeutic application. Here, we present an overview of the recent research into the effects of functional oligosaccharides on intestinal health.

Keywords: functional oligosaccharides; gut microbiota; intestinal barriers; intestinal diseases.

Publication types

  • Review

MeSH terms

  • Homeostasis
  • Humans
  • Inflammatory Bowel Diseases* / drug therapy
  • Intestines
  • Oligosaccharides / therapeutic use

Substances

  • Oligosaccharides

Grants and funding

National Key R&D Program of China grant number 2019YFD0902000.