CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer

Renata Sanches Almeida; Fernanda Wisnieski; Bruno Takao Real Karia; Marilia Arruda Cardoso Smith

doi:10.3390/genes13112029

CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer

Genes (Basel). 2022 Nov 4;13(11):2029. doi: 10.3390/genes13112029.

Authors

Renata Sanches Almeida¹, Fernanda Wisnieski^{1

2}, Bruno Takao Real Karia¹, Marilia Arruda Cardoso Smith¹

Affiliations

¹ Discipline of Genetics, Department of Morphology and Genetics, Federal University of São Paulo, Rua Botucatu, 740, São Paulo 04023900, Brazil.
² Discipline of Gastroenterology, Department of Medicine, Federal University of São Paulo, Rua Loefgreen, 1726, São Paulo 04040002, Brazil.

Abstract

Gastric cancer is the subject of clinical and basic studies due to its high incidence and mortality rates worldwide. Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy and chemotherapy, they are extremely aggressive and limit the quality of life of these patients. CRISPR/Cas9 is a tool that allows gene editing and has been used to explore the functions of genes related to gastric cancer, in addition to being used in the treatment of this neoplasm, greatly increasing our understanding of cancer genomics. In this mini-review, we seek the current status of the CRISPR/Cas9 gene-editing technology in gastric cancer research and clinical research.

Keywords: CRISPR; gastric cancer; gene editing.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

CRISPR-Cas Systems / genetics
Gene Editing* / methods
Humans
Quality of Life
Stomach Neoplasms* / genetics
Stomach Neoplasms* / therapy
Technology

Grants and funding

This study was funded by the São Paulo Research Foundation (FAPESP) under grant numbers 2016/25562-0 and 2019/20592-6; the National Council for Scientific and Technological Development (CNPq) under grant number 2018/301127-2; and the Coordination for the Improvement of Higher Education Personnel (CAPES) under grant numbers 23038051640/2009-01 and 88882.430350/2019-01. M.A.C.S. was funded by FAPESP grant number 2016/25562-0; CNPq grant number 2018/301127-2; and CAPES 23038051640/2009-01. B.T.R.K. was funded by FAPESP grant number 2019/20592-6. R.S.A. was funded by CAPES Doctoral Fellowship 88882.430350/2019-01.