Histone lactylation: a new epigenetic axis for host-parasite signalling in malaria?

Trends Parasitol. 2023 Jan;39(1):12-16. doi: 10.1016/j.pt.2022.10.004. Epub 2022 Nov 7.

Abstract

Epigenetic modifications play important roles in the biology of malaria parasites. The new epigenetic mark histone lactylation, discovered only recently in humans, is also present in malaria parasites. It may have important functions as a key player in the epigenetic repertoire of Plasmodium.

Keywords: Plasmodium; epigenetics; hyperlactataemia; lactate; lactylation; malaria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Epigenesis, Genetic
  • Histones / genetics
  • Histones / metabolism
  • Humans
  • Malaria* / parasitology
  • Parasites* / metabolism
  • Plasmodium falciparum / metabolism

Substances

  • Histones