Sputnik V vaccine-related complications and its impression on inflammatory biomarkers in healthcare providers

Majid Akrami; Hadiseh Hosamirudsari; Neda Faraji; Behnam Behnush; Forough Goudarzi; Elahe Hesari; Samaneh Akbarpour; Arezu Najafi; Saeed Nateghi

doi:10.1016/j.ijmmb.2022.10.012

Sputnik V vaccine-related complications and its impression on inflammatory biomarkers in healthcare providers

Indian J Med Microbiol. 2023 May-Jun:43:79-84. doi: 10.1016/j.ijmmb.2022.10.012. Epub 2022 Nov 7.

Authors

Majid Akrami¹, Hadiseh Hosamirudsari², Neda Faraji³, Behnam Behnush⁴, Forough Goudarzi⁵, Elahe Hesari⁶, Samaneh Akbarpour⁷, Arezu Najafi⁷, Saeed Nateghi⁸

Affiliations

¹ Department of Anesthesiology, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
² Department of Infectious Diseases, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: h-hosami@sina.tums.ac.ir.
³ Department of Internal Medicine, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
⁴ Department of Forensic Medicine. Tehran University of Medical Sciences, Tehran, Iran.
⁵ Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
⁶ School of Public Health, Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.
⁷ Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
⁸ Department of Cardiology, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Purpose: The current pandemic made scientists create new platforms of vaccines to fight against SARS-CoV-2. Without a doubt, the new forms of present vaccines could develop a diversity of unknown complications. Sputnik V vaccine with two different adenovirus vectors (Ad26 priming and Ad5 boost) was first announced safe and effective by Russia. However, there are controversies surrounding this vaccine such as the possible decline of its immunogenicity and diminished neutralizing capacity against some Covid-19 variants. In addition, its impression on serum biomarkers is not clearly surveyed. The present study aimed to evaluate the frequency of Sputnik V vaccine-related complications and its impression on inflammatory and hematologic biomarkers.

Materials &methods: An observational cohort study was performed to evaluate the side effects and serum biomarkers changes in healthcare workers receiving Sputnik V vaccine. The vaccine adverse events were recorded daily within 60 days. The blood samples were obtained before vaccination, and on the10th day after each dose of vaccination. The prevalence of all complications and inflammatory biomarkers levels were compared between two doses. All analyses were performed using SPSS software version 22.0.

Results: Totally, 126 participants completed the study. The mean age was 37.19 ± 7.73 years. The prevalence of all complications was higher following the first dose than the second dose. The most common side effects were pain at the injection site, body pain, fever, headache, weakness, vertigo, sore throat and sleep disorder. The hematocrit, mean corpuscular volume of red blood cells and neutrophils count declined following vaccination significantly (P-value; 0.04, 0.039, 0.000 respectively).

Conclusion: It seems the side effects of Sputnik-V vaccine are mild and decrease significantly after the second dose. The decreasing level of hematocrit, MCV and neutrophil count was found significant following vaccination.

Keywords: Covid-19; Serum biomarker; Side effects; Sputnik-V vaccine.

Publication types

Observational Study

MeSH terms

Adult
Antibodies, Viral
Biomarkers
COVID-19* / prevention & control
Drug-Related Side Effects and Adverse Reactions*
Health Personnel
Humans
SARS-CoV-2

Substances

Biomarkers
Antibodies, Viral

Supplementary concepts

SARS-CoV-2 variants