In the wake of the global pandemic, interacting with others while wearing masks has emerged as a global challenge. A growing body of literature has reported that face masks hinder emotion recognition in Western populations. Given that diagnostic facial features for recognizing specific emotions (e.g., happiness) differ between Western and Eastern cultures, there may be cultural differences in the effects of face masks on emotion recognition. Relying on the previous findings showing cultural differences in emotion recognition, we conducted a preregistered study where 203 American and 209 Japanese participants judged the emotional expressions of faces (happy, fearful, angry, sad, disgust, and neutral) with and without masks. The results showed cultural differences in emotion recognition of faces with and without masks. Specifically, face masks decreased the accuracy of happy emotion recognition in the Americans but not in the Japanese. The results suggest that the effect of wearing masks on emotion recognition depends on the types of emotions and culture and supports previous findings indicating cultural differences in the decoding strategy for facial expressions. (PsycInfo Database Record (c) 2023 APA, all rights reserved).