CoMutDB: the landscape of somatic mutation co-occurrence in cancers

Bioinformatics. 2023 Jan 1;39(1):btac725. doi: 10.1093/bioinformatics/btac725.

Abstract

Motivation: Somatic mutation co-occurrence has been proven to have a profound effect on tumorigenesis. While some studies have been conducted on co-mutations, a centralized resource dedicated to co-mutations in cancer is still lacking.

Results: Using multi-omics data from over 30 000 subjects and 1747 cancer cell lines, we present the Cancer co-mutation database (CoMutDB), the most comprehensive resource devoted to describing cancer co-mutations and their characteristics.

Availability and implementation: The data underlying this article are available in the online database CoMutDB: http://www.innovebioinfo.com/Database/CoMutDB/Home.php.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Carcinogenesis
  • Cell Transformation, Neoplastic
  • Databases, Factual
  • Humans
  • Mutation
  • Neoplasms* / genetics