Modeling and Assessing Osteoarthritis in Mice by Destabilization of the Medial Meniscus (DMM)

Jadwiga Miotla-Zarebska; Ida Parisi; Vicky Batchelor; Tonia L Vincent; Paul K Potter

doi:10.1007/978-1-0716-2839-3_26

Modeling and Assessing Osteoarthritis in Mice by Destabilization of the Medial Meniscus (DMM)

Methods Mol Biol. 2023:2598:357-373. doi: 10.1007/978-1-0716-2839-3_26.

Authors

Jadwiga Miotla-Zarebska¹, Ida Parisi¹, Vicky Batchelor¹, Tonia L Vincent¹, Paul K Potter²

Affiliations

¹ Centre for Osteoarthritis Pathogenesis, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
² Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK. ppotter@brookes.ac.uk.

PMID: 36355305
DOI: 10.1007/978-1-0716-2839-3_26

Abstract

In this chapter, we describe an induced model of osteoarthritis in mice, frequently employed in the study of this disease. We outline in detail the surgical induction of disease and preparation of samples for histological assessment of disease.

Keywords: Bone; Cartilage; Meniscus; Mouse model; Osteoarthritis; Pain.

MeSH terms

Animals
Cartilage, Articular* / pathology
Disease Models, Animal
Menisci, Tibial / pathology
Menisci, Tibial / surgery
Mice
Mice, Inbred C57BL
Osteoarthritis* / pathology