Small-Animal Compression Models of Osteoarthritis

Blaine A Christiansen; Deva D Chan; Marjolein C H van der Meulen; Tristan Maerz

doi:10.1007/978-1-0716-2839-3_25

Small-Animal Compression Models of Osteoarthritis

Methods Mol Biol. 2023:2598:345-356. doi: 10.1007/978-1-0716-2839-3_25.

Authors

Blaine A Christiansen¹, Deva D Chan², Marjolein C H van der Meulen³, Tristan Maerz⁴

Affiliations

¹ University of California Davis Health, Department of Orthopaedic Surgery, Sacramento, CA, USA. bchristiansen@ucdavis.edu.
² Purdue University, Weldon School of Biomedical Engineering, West Lafayette, IN, USA.
³ Cornell University, Meinig School of Biomedical Engineering and Sibley School of Mechanical & Aerospace Engineering, Ithaca, NY, USA.
⁴ University of Michigan, Departments of Orthopaedic Surgery and Biomedical Engineering, Ann Arbor, MI, USA.

Abstract

The utility of nonsurgical, mechanical compression-based joint injury models to study osteoarthritis pathogenesis and treatments is increasing. Joint injury may be induced via cyclic compression loading or acute overloading to induce anterior cruciate ligament rupture. Models utilizing mechanical testing systems are highly repeatable, require little expertise, and result in a predictable onset of osteoarthritis-like pathology on a rapidly progressing timeline. In this chapter, we describe the procedures and equipment needed to perform mechanical compression-induced initiation of osteoarthritis in mice and rats.

Keywords: Animal models; Anterior cruciate ligament; Cartilage; Compression; Injury; Osteoarthritis; Post-traumatic.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Anterior Cruciate Ligament Injuries* / etiology
Anterior Cruciate Ligament Injuries* / pathology
Anterior Cruciate Ligament Injuries* / surgery
Cartilage, Articular* / pathology
Disease Models, Animal
Mice
Osteoarthritis* / etiology
Osteoarthritis* / pathology
Rats

Abstract

Publication types

MeSH terms

Grants and funding