Coding-Complete Genome Sequences for Two Confirmed Monkeypox Cases in South Africa 2022

Wai Yin Chan; Phillip Senzo Mtshali; Antoinette Grobbelaar; Naazneen Moolla; Thabo Mohale; Michelle Lowe; Morne Du Plessis; Arshad Ismail; Jacqueline Weyer

doi:10.1128/mra.00802-22

Coding-Complete Genome Sequences for Two Confirmed Monkeypox Cases in South Africa 2022

Microbiol Resour Announc. 2022 Dec 15;11(12):e0080222. doi: 10.1128/mra.00802-22. Epub 2022 Nov 10.

Authors

Wai Yin Chan^{1

2}, Phillip Senzo Mtshali¹, Antoinette Grobbelaar¹, Naazneen Moolla^{1

3}, Thabo Mohale¹, Michelle Lowe¹, Morne Du Plessis¹, Arshad Ismail^{1

4}, Jacqueline Weyer^{1

3

5}

Affiliations

¹ National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
² Department of Biochemistry, Genetics and Microbiology, Forestry and Agricultural Biotechnology Institute, University of Pretoria, Pretoria, South Africa.
³ Department of Medical Virology, Faculty of Health Sciences, University of Pretoria, Tshwane, South Africa.
⁴ Department of Biochemistry and Microbiology, Faculty of Science, Engineering and Agriculture, University of Venda, Thohoyandou, South Africa.
⁵ Department of Microbiology and Infectious Diseases, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.

Abstract

The coding-complete genome sequences of monkeypox virus (MPXV) were obtained from skin lesion swabs from two human cases detected in South Africa in June 2022. Sequence analyses indicated that the genetic sequences of the viruses associated with these two cases were related most closely to the genetic sequences of other MPXVs reported during the 2022 multicountry outbreak and belong to the monkeypox hMPXV-1 clade (previously West Africa clade) and B.1 lineage.

Grants and funding

National Health Laboratory Service (NHLS)