Mechanisms of cancer metastasis

Maria Castaneda; Petra den Hollander; Nick A Kuburich; Jeffrey M Rosen; Sendurai A Mani

doi:10.1016/j.semcancer.2022.10.006

Mechanisms of cancer metastasis

Semin Cancer Biol. 2022 Dec:87:17-31. doi: 10.1016/j.semcancer.2022.10.006. Epub 2022 Oct 27.

Authors

Maria Castaneda¹, Petra den Hollander², Nick A Kuburich², Jeffrey M Rosen³, Sendurai A Mani⁴

Affiliations

¹ Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA.
² Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pathology and Lab Medicine, Brown University, Providence, RI 02912, USA; Legoretta Cancer Center, Brown University, Providence, RI 021912, USA.
³ Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: Jrosen@bcm.edu.
⁴ Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pathology and Lab Medicine, Brown University, Providence, RI 02912, USA; Legoretta Cancer Center, Brown University, Providence, RI 021912, USA. Electronic address: mani@brown.edu.

PMID: 36354098
DOI: 10.1016/j.semcancer.2022.10.006

Abstract

Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from metastatic disease. Combating cancer metastasis and post-therapeutic recurrence successfully requires understanding each step of metastatic progression. This review describes the current state of knowledge of the etiology and mechanism of cancer progression from primary tumor growth to the formation of new tumors in other parts of the body. Open questions, avenues for future research, and therapeutic approaches with the potential to prevent or inhibit metastasis through personalization to each patient's mutation and/or immune profile are also highlighted.

Keywords: Cancer metastasis; Epithelial-mesenchymal plasticity; Epithelial-mesenchymal transition; Extravasation; Invasion.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural

MeSH terms

Epithelial-Mesenchymal Transition* / genetics
Humans
Neoplasm Metastasis
Neoplasms* / genetics
Neoplasms* / pathology

Abstract

Publication types

MeSH terms

Grants and funding