A longitudinal study on associations of moderate-to-vigorous physical activity with plasma monounsaturated fatty acids in pregnancy

Tong Xia; Liwei Chen; Zhe Fei; Xinyue Liu; Jin Dai; Stefanie N Hinkle; Yeyi Zhu; Jing Wu; Natalie L Weir; Michael Y Tsai; Cuilin Zhang

doi:10.3389/fnut.2022.983418

A longitudinal study on associations of moderate-to-vigorous physical activity with plasma monounsaturated fatty acids in pregnancy

Front Nutr. 2022 Oct 24:9:983418. doi: 10.3389/fnut.2022.983418. eCollection 2022.

Authors

Tong Xia¹, Liwei Chen¹, Zhe Fei², Xinyue Liu¹, Jin Dai¹, Stefanie N Hinkle³, Yeyi Zhu⁴, Jing Wu⁵, Natalie L Weir⁶, Michael Y Tsai⁶, Cuilin Zhang^{7

8}

Affiliations

¹ Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States.
² Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States.
³ Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
⁴ Division of Research, Kaiser Permanente Northern California, Oakland, CA, United States.
⁵ Glotech, Inc., Rockville, MD, United States.
⁶ Department of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN, United States.
⁷ Global Center for Asian Women's Health, Bia-Echo Asia Centre for Reproductive Longevity & Equality, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
⁸ Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Abstract

Background: Physical activity (PA) during pregnancy influences women and offspring's health via fatty acids metabolism. However, studies on associations of PA with plasma monounsaturated fatty acids (MUFAs) across pregnancy are sparse. Thus, our study aimed to examine associations of PA with individual plasma phospholipid MUFAs throughout pregnancy in a prospective and longitudinal study in the United States (US).

Materials and methods: The study included 318 pregnant women from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies-Singletons cohort. PA was measured four times: PA reported at 10-14 gestational weeks (GWs) representing PA in the past year, and at 15-26 GWs, 23-31 GWs, and 33-39 GWs representing PA since the last visit. Plasma phospholipid MUFAs were measured at the same four visits as the measurement of PA. Associations between moderate-to-vigorous PA (MVPA) and the total MUFAs and seven individual plasma phospholipid MUFAs (i.e., palmitoleic acid, 18:1n6-9 trans, 18:1n6c, cis-vaccenic acid, oleic acid, eicosenoic acid, and nervonic acid) were assessed at each visit using multivariable linear regression models adjusting for confounders.

Results: MVPA (hours/week) reported at 15-26 GWs representing MVPA since the last visit was positively associated with total MUFAs (% of total fatty acids) [adjusted β*10² (standard error (SE)*10²) = 10.41 (3.19), P = 0.001] at 15-26 GWs. For individual MUFAs, MVPA reported at 15-26 GWs representing MVPA since the last visit was positively associated with oleic acid [adjusted β*10² (SE*10²) = 8.56 (2.65), P = 0.001] and eicosenoic acid [adjusted β*10² (SE*10²) = 0.55 (0.20), P = 0.01] at 15-26 GWs. MVPA reported at 23-31 GWs representing MVPA since the last visit was positively associated with palmitoleic acid [adjusted β*10² (SE*10²) = 2.24 (0.64), P = 0.001] at 23-31 GWs. MVPA reported at 10-14 GWs and 33-39 GWs was not associated with total or individual MUFAs.

Conclusion: We found novel positive associations of MVPA with individual MUFAs, such as oleic acid, eicosenoic acid, and palmitoleic acid, during middle-to-late pregnancy. These findings suggest that MVPA represents a potentially modifiable factor for plasma individual MUFA levels during pregnancy.

Keywords: fatty acids; moderate-to-vigorous physical activity; monounsaturated fatty acids; physical activity; pregnant women.