An embarrassment of riches: RORγt+ antigen-presenting cells in peripheral tolerance

Emmanuel Stephen-Victor; Talal A Chatila

doi:10.1016/j.immuni.2022.10.009

An embarrassment of riches: RORγt⁺ antigen-presenting cells in peripheral tolerance

Immunity. 2022 Nov 8;55(11):1978-1980. doi: 10.1016/j.immuni.2022.10.009.

Authors

Emmanuel Stephen-Victor¹, Talal A Chatila²

Affiliations

¹ Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
² Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: talal.chatila@childrens.harvard.edu.

Abstract

RORγt⁺ regulatory T (Treg) cells are critical toward maintaining gut immune tolerance. In recent studies published in Nature, Kedmi et al., Lyu et al., and Akagbosu et al. describe MHCII⁺RORγt⁺ antigen-presenting cells that mediate RORγt⁺ Treg cell differentiation but propose disparate identities for these cells.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Antigen-Presenting Cells
Embarrassment
Forkhead Transcription Factors
Immune Tolerance
Nuclear Receptor Subfamily 1, Group F, Member 3*
Peripheral Tolerance*
T-Lymphocytes, Regulatory
Th17 Cells

Substances

Nuclear Receptor Subfamily 1, Group F, Member 3
Forkhead Transcription Factors

Grants and funding

R01 AI126915/AI/NIAID NIH HHS/United States