Hydrophobic deep eutectic solvents in the food sector: Focus on their use for the extraction of bioactive compounds

Lucia Sportiello; Fabio Favati; Nicola Condelli; Maria Di Cairano; Marisa Carmela Caruso; Barbara Simonato; Roberta Tolve; Fernanda Galgano

doi:10.1016/j.foodchem.2022.134703

Hydrophobic deep eutectic solvents in the food sector: Focus on their use for the extraction of bioactive compounds

Food Chem. 2023 Mar 30;405(Pt A):134703. doi: 10.1016/j.foodchem.2022.134703. Epub 2022 Nov 1.

Authors

Lucia Sportiello¹, Fabio Favati², Nicola Condelli³, Maria Di Cairano⁴, Marisa Carmela Caruso⁵, Barbara Simonato⁶, Roberta Tolve⁷, Fernanda Galgano⁸

Affiliations

¹ Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy; School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy. Electronic address: lucia.sportiello@unibas.it.
² Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy. Electronic address: fabio.favati@univr.it.
³ School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy. Electronic address: nicola.condelli@unibas.it.
⁴ School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy. Electronic address: maria.dicairano@unibas.it.
⁵ School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy. Electronic address: marisa.caruso@unibas.it.
⁶ Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy. Electronic address: barbara.simonato@univr.it.
⁷ Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy. Electronic address: roberta.tolve@univr.it.
⁸ School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy. Electronic address: fernanda.galgano@unibas.it.

PMID: 36351313
DOI: 10.1016/j.foodchem.2022.134703

Abstract

Hydrophobic Deep Eutectic Solvents (HDESs) represent a novel kind of solvent. While several studies investigated their properties, just a few dealt with their use for extracting and recovering bioactive compounds from raw materials, wastes and by-products, even if HDESs might represent an interesting alternative when producing pharmaceuticals, foodstuffs and cosmetics. Furthermore, their use may contribute to realizing more sustainable green processes. This review focuses on HDESs, with particular emphasis on Natural HDESs, discussing their properties and uses, highlighting their role as extractants in food applications, both from an analytical and processing point of view, and underlining the positive and negative aspects. While of prospective interest, currently the use of HDESs at industrial level remains a challenge, with several aspects needing further investigation. In order to scale-up the process, more research should focus on key issues, such as solute recovery, solvent recycling and extraction yields, as well as potential health hazards.

Keywords: Bioactive compounds; Environmental sustainability; Green chemistry; Hydrophobic deep eutectic solvents.

Publication types

Review

MeSH terms

Deep Eutectic Solvents*
Food*
Hydrophobic and Hydrophilic Interactions
Prospective Studies
Solvents / chemistry

Substances

Deep Eutectic Solvents
Solvents