Two new lignans (1-2) and a new octaketide (12), together with twenty-nine known compounds (3-11, 13-32) were isolated and identified from the aerial part of Pogostemon cablin. Their chemical structures were revealed mainly through NMR and MS data. The absolute configuration of 1 and 2 was deduced by comparing its experimental CD with the calculated ECD spectra. The inhibitory activities of the isolated compounds on LPS-stimulated nitric oxide (NO) production in RAW 264.7 cells were investigated. At a concentration of 25 μM, compounds 1 and 11 showed approximately equal NO inhibitory effects to that of aminoguanidine.
Keywords: ECD; Pogostemon cablin; anti-inflammatory activities; lignans; phenylethanoid glycosides.
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